This dissertation studies the fine-grained complexity of model checking problems for fixed logical formulas on sparse input structures. The Orthogonal Vectors problem is an important and well-studied problem in fine-grained complexity: its hardness is implied by the Strong Exponential Time Hypothesis, and its hardness implies the hardness of many other interesting problems. We show that the Orthogonal Vectors problem is complete in the class of first-order model checking on sparse structures, under fine-grained reductions. In other words, the hardness of Orthogonal Vectors and the hardness of first-order model checking imply each other. This also gives us an improved algorithm for first-order model checking problems. Among all first-order logic formulas in prenex normal form, we have reasons to believe that quantifier structures ∃…∃∀ and ∀…∀∃ may be the hardest in computational complexity: If the Nondeterministic version of the Strong Exponential Time Hypothesis is true, formulas of these forms are the only hard ones under the Strong Exponential Time Hypothesis. We can add extensions to first-order logic to strengthen its expressive power. This work also studies the fine-grained complexity of first-order formulas with comparison on structures with total order, first-order formulas with transitive closure operations, first-order formulas of fixed quantifier rank, and first-order formulas of fixed variable complexity. We also introduce a technique that can be used to reduce from sequential problems on graphs to parallel problems on sets, which can be applied to extending the Least Weight Subsequence problems from linear structures to some special classes of graphs
