Creytens, David

D'Asseler, Yves

Debacker, Jens

Goethals, Ingeborg

Huvenne, Wouter

Keereman, Vincent

Marcinkowski, Radoslaw

Van Holen, Roel

Ghent University Academic Bibliography

PROPOSED METHODOLOGYPROBLEM & PROPOSED SOLUTIONThere is currently no ideal method for identifying the tumor margin status during surgery in a reliable and time efficient manner. Identifying tumor-infiltrated margins peroperatively would allow complete resection of the primary tumor if necessary. We propose using per-operative high-resolution 18F-FDG PET/CT of the excised tumor specimen to identify residual tumor-infiltrated margins and lymph nodes.²PREVIOUS WORK ‒ Proof-of-concept study in breast conserving surgery ‒ Sensitivity: 88% ‒ Specificity: 80% 1 Liao, Chun-Ta, et al. Annals of Surgical Oncology 15.3 (2008): 915-922. 2  España, Samuel, et al. Physics in Medicine & Biology 59.13 (2014): 3405. CONCLUSIONThe proposed methodology for using micro-PET/CT specimen imaging is a promising technique for the intraoperative tumor margin assessment of head and neck squamous cell carcinomas of the oral cavity. The aim of the current study is to further evaluate the feasibility of high-resolution 18F-FDG-PET/CT for intraoperative margin assessment of resected squamous cell carcinomas of the head and neck region and compare the results to the gold standard. HIGH-RESOLUTION PET/CT ‒ Technical specifications ‒ CT: spatial resolution of 50 μm  ‒ PET: spatial resolution of 0.85 mm / sensitivity of 12% ‒ System dimensions of 55 x 55 x 55 cm³ ‒ Advantages ‒ Small footprint ‒ Sub-millimeter PET resolution ‒ Short acquisition timePEROPERATIVE ASSESSMENT OF TUMOR RESECTION MARGINS USING HIGH-RESOLUTION PET/CT IN ORAL CARCINOMA, A FEASIBILITY CLINICAL TRIAL. Debacker J.1, Marcinkowski R.², Keereman V.², D’Asseler Y.3,4, Goethals I. 3,4 , Creytens D.3,5, Van Holen R.², Huvenne W.1,61 Department of Head and Skin, Ghent University, Ghent, Belgium2 Molecubes NV, Ghent, Belgium3 Department of Diagnostic Sciences, Ghent University, Ghent, Belgium4 Department of Nuclear Medicine, Ghent University Hospital, Ghent, Belgium5 Department of Anatomical pathology, Ghent University Hospital Ghent, Belgium6 Department of Head and Neck Surgery, Ghent University Hospital Ghent, BelgiumSTEP 1: ANESTHESIAGeneral anesthesia will be administered as per local protocol.STEP 2: RADIONUCLIDE INJECTION 18F-FDG will be administered intravenously in the operating room. STEP 3: TUMOR RESECTIONTumor excision and lymphadenectomy will start at least 45-60 minutes post-injection. STEP 4: µPET/CTBoth primary tumor and lymphadenectomy samples will  be imaged using the high  resolution PET/CT. STEP 5: HISTOPATHOLOGYStandard histopathological examination will be performed to obtain the gold standard result.Microscopically tumor-infiltrated margins and lymph nodes in the treatment of oral squamous cell carcinomas result in a significantly increased locoregional recurrence rate, associated with an important reduction in overall survival.1 The current standard of practice for assessing the margin status is to perform frozen section analysis of samples taken from the resection cavity, but this is both time consuming and prone to sampling bias.BACKGROUNDCONTACT jensm.debacker@ugent.be  Universiteit Gent  @ugent  Ghent University

Peroperative assessment of tumor resection margins using high-resolution PET/CT in oral carcinoma, a feasibility clinical trial.

https://biblio.ugent.be/publication/8627312/file/8627313.pdf

Peroperative assessment of tumor resection margins using high-resolution PET/CT in oral carcinoma, a feasibility clinical trial.

Abstract

Similar works

Full text

Available Versions

Ghent University Academic Bibliography