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Antagonistic activities of some probiotic lactobacilli culture supernatant on serratia marcescens swarming motility and antibiotic resistance
Authors
M.M. Feizabadi
P. Ghadam
+4 more
R. Kasra-Kermanshahi
M. Shokouhfard
S. Teimourian
R. Vahedi-Shahandashti
Publication date
1 January 2017
Publisher
Tehran University of Medical Science
Abstract
Background and Objectives: Serratia marcescens, a potentially pathogenic bacterium, benefits from its swarming motility and resistance to antibiotic as two important virulence factors. Inappropriate use of antibiotics often results in drug resistance phenomenon in bacterial population. Use of probiotic bacteria has been recommended as partial replacement. In this study, we investigated the effects of some lactobacilli culture supernatant on swarming, motility and antibiotic resistance of S. marcescens. Materials and Methods: Antimicrobial activity of lactobacilli supernatant and susceptibility testing carried out on S. marcescens isolates. Pretreatment effect of lactobacilli culture supernatant on antibiotic - resistance pattern in S. marcescens was determined by comparison of the MIC of bacteria before and after the treatment. Results: Our results showed that pretreatment with L. acidophilus ATCC 4356 supernatant can affect the resistance of Serratia strains against ceftriaxone, but it had no effect on the resistance to other antibiotics. Furthermore, culture supernatant of lactobacilli with concentrations greater than 2, had an effect on the swarming ability of S. marcescens ATCC 13880 and inhibited it. Conclusion: Probiotic bacteria and their metabolites have the ability to inhibit virulence factors such as antibiotic resistance and swarming motility and can be used as alternatives to antibiotics. © 2018, Tehran University of Medical Science. All rights reserved
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eprints Iran University of Medical Sciences
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oai:eprints.iums.ac.ir:7653
Last time updated on 10/10/2019