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Potentiometric sensing of lamotrigine based on molecularly imprinted polymers
Authors
H. Afifinia
N. Almasian
+5 more
F. Bozorgvar
S.A. Ebrahimi
S. Mollaei
H.B. Sadeghi
A. Tamaddon
Publication date
1 January 2011
Publisher
Abstract
In the present work a novel potentiometric sensor, based on a noncovalent imprinted polymer, was developed for determination of Lamotrigine (LTG). At optimized conditions the electrode exhibited a Nernstian response (30.8±1.0mV decade-1) in a concentration range of 1�10-6 to 1�10-3M with a detection limit of 8�10-7mol L-1. The potential response of the electrode was constant in the pH range of 1.0-5.0. The electrode demonstrated a response time of ~30s. The selectivity coefficient of the sensor toward a number of different drugs with molecular similarities and some metal ions was evaluated. The electrode was examined for determination of LTG in real samples. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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eprints Iran University of Medical Sciences
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Last time updated on 10/10/2019