Potentiometric sensing of lamotrigine based on molecularly imprinted polymers

Abstract

In the present work a novel potentiometric sensor, based on a noncovalent imprinted polymer, was developed for determination of Lamotrigine (LTG). At optimized conditions the electrode exhibited a Nernstian response (30.8±1.0mV decade-1) in a concentration range of 1�10-6 to 1�10-3M with a detection limit of 8�10-7mol L-1. The potential response of the electrode was constant in the pH range of 1.0-5.0. The electrode demonstrated a response time of ~30s. The selectivity coefficient of the sensor toward a number of different drugs with molecular similarities and some metal ions was evaluated. The electrode was examined for determination of LTG in real samples. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim