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Single nucleotide polymorphisms of the genes encoding IL-10 and TGF-β1 in Iranian children with atopic dermatitis
Authors
A. Aghamohammadi
A.A. Amirzargar
+10 more
N. Behniafard
F. Delavari
E. Farhadi
M. Gharagozlou
S. Hosseinverdi
M. Khaledi
M. Mahmoudi
Z.G. Moghaddam
N. Rezaei
S. Sotoudeh
Publication date
1 January 2018
Publisher
Abstract
Background: Atopic dermatitis is an inflammatory skin disease in which both genetic and environmental factors interact to determine the susceptibility and severity of the disease. Objective: The aim of this study was to determine the association between atopic dermatitis and IL-10 and TGF-β1 gene polymorphisms. Methods: The allele and genotype frequencies of genes encoding for IL-10 and TGF-β1 were investigated in 89 patients with atopic dermatitis in comparison with 138 in the control group using the PCR-SSP method. Results: A significant increase was found in the frequency of the TGF-β1 codon 10/C allele among patients (p < 0.001, OR = 6.77), whereas a significant decrease was observed in the frequency of the T allele at the same position (p < 0.001, OR = 0.14). The frequency of the TGF-β1 codon 25/G allele in the control group was significantly higher than among patients (p < 0.001, OR = 0.08). A significant positive correlation was seen between CC (p < 0.001, OR = 15.10) and CG (p < 0.001) genotypes and AD at codons 10 and 25, respectively. The most frequent haplotypes among patients was TGF-β1 CG which was significantly higher than in the control subjects (50 in patients vs. 39.9 in controls, p = 0.042). A significant increase was found in the frequency of TGF-β CC (36 in patients vs. 7.6 in controls, p < 0.001) and TC (14 in patients vs. 0 in controls, p < 0.001) haplotypes among patients compared to controls. By contrast, the TGF-β1 TG haplotype was significantly lower in patients than controls (0 in patients vs. 52.5 in controls, p < 0.001). There were no significant differences in the frequency of alleles, genotypes and haplotypes of the IL-10 gene. Conclusions: We found a strong association between the polymorphisms of the TGF-β1 gene at codon 10 and codon 25 positions and atopic dermatitis. © 2017 SEICA
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Last time updated on 10/10/2019