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A comparative study between platelet-rich plasma and platelet-poor plasma effects on angiogenesis
Authors
M.K. Arami
N. Esmaeili
+5 more
S. Hydarporian
S. Jafari
F. Sadeghi Shirazi
M. Shahidi
M. Vatanmakanian
Publication date
1 January 2018
Publisher
Abstract
Platelet-rich plasma (PRP) has been established as an autologous source for therapeutic angiogenesis. The purpose of this study was to evaluate PRP angiogenic effects compared to platelet-poor plasma (PPP) in vitro and in vivo. The effects of PRP on vascular endothelial growth factor receptor-2 (VEGFR2) and CD34 expression were evaluated using real-time PCR, flow cytometry, western blot, immunocytochemistry and pathological study, as were carried out in both human umbilical endothelial cell culture and rat skin. Our findings indicated significant effect of PRP and PPP on VEGFR2 and CD34 expression by human umbilical vein endothelial cells, which was greater in latter. These effects, however, were confirmed by demonstrating an earlier angiogenic effect of PPP in vivo when compared to PRP. The findings of the present study as the first comparative study of PRP versus PPP are novel. Nevertheless, further studies are needed to clarify the underlying mechanism of these findings to improve the therapeutic effects of PRP and PPP. © 2017, The Japanese Society for Clinical Molecular Morphology
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eprints Iran University of Medical Sciences
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oai:eprints.iums.ac.ir:540
Last time updated on 10/10/2019
eprints Iran University of Medical Sciences
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:eprints.iums.ac.ir:6873
Last time updated on 10/10/2019