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Prevalence and genetic diversity of norovirus genogroup II in children less than 5 years of age with acute gastroenteritis in Tehran, Iran
Authors
A. Arashkia
M. Farsi
+7 more
S. Jalilvand
S.M. Marashi
A. Nateghian
B. Nejati
A. Rahbarimanesh
F. Roodbari
Z. Shoja
Publication date
1 January 2018
Publisher
Abstract
Viral gastroenteritis is a major public health problem worldwide. In Iran, very limited studies have been performed with regard to the epidemiology of noroviruses. This study aimed to evaluate the prevalence and molecular epidemiology of GII noroviruses in hospitalized children less than 5 years of age with acute gastroenteritis (AGE). A total of 210 stool specimens were collected from Ali Asghar Childrenâ��s Hospital and Bahrami Childrenâ��s Hospital in Tehran, from June 2015 to June 2016. The samples were screened by real-time RT-PCR for genogroup II (GII). Positive samples were genotyped by semi-nested PCR followed by Sanger sequencing and phylogenetic analysis. Norovirus was identified in 36 (17.1) of 210 specimens. Based on genetic analysis of RdRp and capsid sequences, the strains were clustered into eight RdRpâ��capsid genotypes: GII.P4â��GII.4 Sydney₂₀₁₂ (41.7), GII.Peâ��GII.4 Sydney₂₀₁₂ (30.6), GII.P21â��GII.3 (13.9), GII.P16â��GII.4 Sydney₂₀₁₂ (2.8), GII.P16â��GII.12 (2.8), GII.P2â��GII.4 Sydney₂₀₁₂ (2.8), GII.P7â��GII.7 (2.8) and GII.P2â��GII.2 (2.8). We determined several different co-circulating norovirus genotypes in children < 5 years of age with AGE in our hospital in Tehran, Iran. Continued molecular surveillance of noroviruses, including typing of both RdRp and capsid genes, is important for monitoring emerging strains in our continued efforts to reduce the overall burden of norovirus disease. © 2018 Springer-Verlag GmbH Germany, part of Springer Natur
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eprints Iran University of Medical Sciences
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oai:eprints.iums.ac.ir:6341
Last time updated on 10/10/2019
eprints Iran University of Medical Sciences
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:eprints.iums.ac.ir:392
Last time updated on 10/10/2019