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Atorvastatin treatment softens human red blood cells: An optical tweezers study
Authors
A. Azadbakht
M. Babaei
+5 more
A. Mashaghi
A.A. Moosavi-Movahedi
H. Pazoki-Toroudi
S.N.S. Reihani
V. Sheikh-Hasani
Publication date
1 January 2018
Publisher
Abstract
Optical tweezers are proven indispensable single-cell micro-manipulation and mechanical phenotyping tools. In this study, we have used optical tweezers for measuring the viscoelastic properties of human red blood cells (RBCs). Comparison of the viscoelastic features of the healthy fresh and atorvastatin treated cells revealed that the drug softens the cells. Using a simple modeling approach, we proposed a molecular model that explains the drug-induced softening of the RBC membrane. Our results suggest that direct interactions between the drug and cytoskeletal components underlie the drug-induced softening of the cells. © 2018 Optical Society of America
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eprints Iran University of Medical Sciences
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oai:eprints.iums.ac.ir:6086
Last time updated on 13/08/2020
eprints Iran University of Medical Sciences
See this paper in CORE
Go to the repository landing page
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oai:eprints.iums.ac.ir:585
Last time updated on 10/10/2019