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Dietary flavanones and citrus fruits influence cytokines and thyroid transcription factor-1 in an HDM-induced chronic asthma murine model
Authors
K. Ansarin
A. Barzegari
+6 more
S. Kolahian
A. Sabri
E. Sakhinia
E. Seyedrezazadeh
A.-A. Shahbazfar
M. Vafa
Publication date
1 January 2016
Publisher
Abstract
The effects of hesperetin plus naringenin, orange juice and grapefruit juice on mRNA expression of TNF-α, TGF-β1 and TTF-1 in a house dust mite (HDM)-induced asthma animal model were investigated. Interventional mice exposed to HDM for 6 weeks received hesperetin plus naringenin, orange plus grapefruit juice, orange juice, grapefruit juice or water during the last 4 weeks, whereas non-asthmatic control mice consumed water. Lung tissue TNF-α and TGF-β1 expressions in supplemented groups were significantly reduced (p�<�0.0001 and p�<�0.001, respectively) compared with asthmatic controls. Hesperetin plus naringenin and orange plus grapefruit juice intake reduced expression of TGF-β1 more than grapefruit juice (p���0.02) or orange juice compared with the asthmatic control group. All supplemented groups had non-significantly higher TTF-1 expression compared with water intake groups. Orange plus grapefruit juice or hesperetin plus naringenin with down-regulation of TNF-α and TGF-β1 may ameliorate lung damage in the lung tissue of asthmatic subjects. © 2016 Elsevier Lt
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eprints Iran University of Medical Sciences
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Last time updated on 10/10/2019