CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
The effects of helicobacter pylori eradication on modification of metabolic syndrome parameters in patients with functional dyspepsia
Authors
M. Arshad
M. Bahardoust
+5 more
M. Masoodi
H. Mirfakhraee
M. Mokhtare
A. Movahed
S.H. Samadani Fard
Publication date
1 January 2017
Publisher
Abstract
Background Helicobactor pylori (H. pylori) have the potential role in the pathogenesis of various extra-gastric disorders such as metabolic disorders. But, it is now questioned about whether H. pylori eradication reduces or induces the risk for metabolic disorders especially in patients with dyspepsia. Hence, the present study aimed to assess the effects of H. pylori eradication on criteria of metabolic syndrome. Methods H. pylori infected patients with dyspepsia were included. The patients were treated with omeprazole (20 mg, q12 h), amoxicillin (1 g, q12 h), and clarithromycin (500 mg, q12 h) for two weeks, then H. pylori eradication was evaluated by C14 Breathing test (UBT) 6 weeks after the end of the treatment. Demographic data, clinical manifestation and metabolic parameters were recorded before and three months after completing treatment regimen. The data was analyzed by SPSS version 16.0. Results Of 110 patients were initially enrolled, 91 patients completed the study. Overall eradication rate was 61.5. Significant differences in the serum level of total cholesterol(180.7 ± 34 vs. 172.1 ± 28, p = 0.001), LDL(107.0 ± 25 vs. 100.8 ± 20, p < 0.001), HDL(46.2 ± 8.7 vs. 48.9 ± 8.6, p < 0.001), fasting blood sugar (93.7 ± 12 vs. 90.9 ± 10, p = 0.001), hemoglobin A1c(5.37 ± 0.52 vs 5.25 ± 0.53, p = 0.006), and as well as for waist circumference(92.2 ± 14 vs. 91.4 ± 13.9, p = 0.03) was found after treatment. Data for body weight, systolic and diastolic blood pressure and triglyceride level remained without any significant changes. Conclusion H. pylori eradication could relatively reduce the risk of metabolic syndrome criteria such as fasting blood sugar, hemoglobin A1c, lipid profile and waist circumference. © 2017 Diabetes Indi
Similar works
Full text
Available Versions
eprints Iran University of Medical Sciences
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:eprints.iums.ac.ir:1032
Last time updated on 10/10/2019
eprints Iran University of Medical Sciences
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:eprints.iums.ac.ir:7579
Last time updated on 10/10/2019