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Biochemical pathway analysis of gastric atrophy
Authors
F.T. Rostami
M.R. Tavirani
S.R. Tavirani
Publication date
1 January 2018
Publisher
Abstract
Aim: Pathway analysis of gastric atrophy to find new molecular prospective of disease. Background: Gastric atrophy as a process which is accompanied with "loss of glans" in stomach can be considered as a risk factor of gastric cancer. Here, the correlated biochemical pathways to the disorder have been analyzed via protein-protein interaction (PPI) network analysis. Methods: The genes related to gastric atrophy were retrieved by STRING database and organized in a network by Cytoscape. Three significant clusters were determined by ClusterONE plug-in of Cytoscape. The elements of cluster-2 which contained all central nodes of the network were enriched by ClueGO and the biochemical pathways discussed in details. Results: The number of seven central nodes (which are included in cluster-2); INS, TP53, IL6, TNF, SRC, MYC, and IL8 were identified. The biochemical pathways related to the elements of cluster-2 were determined and clustered in nine groups. The pathways were discussed in details. Conclusion: Pathway analysis indicates that the introduced central genes of the network can be considered as biomarkers of gastric atrophy. ©2018 RIGLD, Research Institute for Gastroenterology and Liver Diseases
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eprints Iran University of Medical Sciences
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oai:eprints.iums.ac.ir:7218
Last time updated on 10/10/2019
eprints Iran University of Medical Sciences
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:eprints.iums.ac.ir:812
Last time updated on 10/10/2019