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Protective Effect of Ocimum basilicum Essential Oil Against Acetic Acid�Induced Colitis in Rats
Authors
A.R. Ghannadi
S. Mehrzadi
+3 more
M. Minaiyan
A. Rashidian
P. Roohi
Publication date
1 January 2016
Publisher
Abstract
Ocimum basilicum L has been traditionally used for the treatment of inflammatory bowel disease in Iran. This study investigates the ameliorative effect of Ocimum basilicum essential oil on an acetic acid�induced colitis model in rats. Ocimum basilicum essential oil with 2 doses (200 and 400 μL/kg) significantly ameliorated wet weight/length ratio of colonic tissue compared to the control group. Higher doses of essential oil (200 and 400 μL/kg) significantly reduced ulcer severity, ulcer area, and ulcer index. On the other hand, histological examination revealed the diminution of total colitis index as a marker for inflammatory cell infiltration in the colonic segments of rats treated with Ocimum basilicum essential oil (200 and 400 μL/kg). The increased level of myeloperoxidase was significantly decreased after the treatment with the essential oil (200 and 400 μL/kg). These results suggest that Ocimum basilicum exhibits protective effect against acetic acid�induced colitis. © 2015, © The Author(s) 2015
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eprints Iran University of Medical Sciences
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oai:eprints.iums.ac.ir:3204
Last time updated on 10/10/2019