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Study of the relationship between HPA-1 and HPA-5 gene polymorphisms and refractory to platelet therapy and recombinant factor VII in glanzmann thrombasthenia patients in Southeast of Iran
Authors
S. Alizadeh
A. Dorgalaleh
+5 more
M. Habibpour
M.A. Issah
Z.K. Khatib
F. Naadali
M. Naderi
Publication date
1 January 2018
Publisher
Abstract
Background: Glanzmann Thrombasthenia (GT) is a rare autosomal disease. HPA (Human Platelet Alloantigen) is a surface polymorphic alloantigen of platelets. This study was intended to investigate and compare the polymorphism of HPA-1 and HPA-5 genes in two groups of GT patients, with and without resistance to platelet and recombinant factor VII therapy. Materials and Methods: This case control study was performed on GT patients (n=16) with resistance to platelet therapy and recombinant factor VII and control group of GT patients (n=16) without resistance to platelet therapy and recombinant factor VII. The consent form was completed by each patient. Gene polymorphisms of HPA-1 and HPA-5 were investigated using SSP-PCR, and the obtained data were analyzed using statistical software SPSS16.0. Results: The results indicated no significant relationship between the studied genes and their resistance to platelet therapy and recombinant factor VII. The frequencies of HPA-1 genotype a/a were 98 and 94 in patient and control groups, respectively. The frequency of allele b was found to be less than allele a. The value of this allele was 4 in patient group and 1 in control group. In addition, the HPA-5a/a (98) was the most frequent alloantigen?? (check it) in both groups. Seven percent (7) of the patients had the HPA-5a/b genotype, and the HPA-5b/b was found to be absent in these individuals. Conclusion: According to the results obtained, it could be concluded that these genes play no role in resistance to platelet therapy. © 2018, Tehran University of Medical Sciences (TUMS). All rights reserved
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eprints Iran University of Medical Sciences
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oai:eprints.iums.ac.ir:961
Last time updated on 10/10/2019
eprints Iran University of Medical Sciences
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:eprints.iums.ac.ir:7214
Last time updated on 10/10/2019