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Interpretation of tongue squamous cell carcinoma via protein-protein interaction network construction and analysis
Authors
V. Mansouri
M. Rezaei-Tavirani
+3Β more
M. Rezaei-Tavirani
R. Vafaee
M. Zamanian Azodi
Publication date
1 January 2018
Publisher
Abstract
Background: Tongue squamous cell carcinoma is one of the prominent cancers in the oral cavity. Molecular investigations based on interaction analysis can be promising towards providing a better resolution of malignant neoplasms. Here, the protein-protein interaction network of tongue cancer is studied. Methods: The protein-protein interaction network was constructed by the application of Cytoscape 3.5.1 and the related algorithms. Centrality analysis via the degree, betweenness, and closeness centralities was conducted. Results: The result indicated that there are seven chief proteins in the network foundation. Moreover, enrichment evaluation suggested two associated biological processes including Response to UV-A, Response to interlukin-7, cellular response to alcohol, and catenin import into nucleus process using CluePedia. Conclusions: It can be concluded that the identified central panel proteins and their related biological processes can shed light on the neoplasm mechanisms and are worth pursuing for clinical approaches. ΓΒ© 2018, Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences
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eprints Iran University of Medical Sciences
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oai:eprints.iums.ac.ir:7106
Last time updated on 10/10/2019
eprints Iran University of Medical Sciences
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:eprints.iums.ac.ir:838
Last time updated on 10/10/2019