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The effects of superovulation with gonadotropins on autoantibody levels in patients undergoing assisted reproductive cycles
Authors
E. Amirchaghmaghi
A. Arabipoor
+3 more
M. Ashrafi
R. Salman-Yazdi
S. Vesali
Publication date
1 January 2018
Publisher
Abstract
Purpose: To evaluate the effect of controlled ovarian stimulation (COH) with gonadotropins on the serum levels of autoantibodies in the women who underwent in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles and to compare basal levels of these autoantibodies between groups according to history of COH. Methods: This prospective cohort study was performed from October 2014 to March 2016 in the Royan Institute. The volunteered infertile women with regard to the inclusion criteria, who underwent IVF/ICSI cycles, were recruited. The COH was performed according to standard long GnRH agonist protocol. The mean levels of the autoantibodies including anti-nuclear, anti-smooth muscle, anti-ovarian, anti-mitochondrial, anti β2-glycoprotein I, anti-parietal cell and anti-follicle-stimulating hormone antibodies were measured at three time points: on the 3�5 days of the menstrual cycle, 1 week after starting of COH and the ovum pick-up (OPU) day. Results: Of all participants (n = 189), 73 women had history of COH (group B) and 116 women did not have such history (group A). The analysis indicated that the autoantibodies changes during COH were similar in both groups. COH has no significant impact on the level of autoantibodies during the stimulation cycle. Multiple logistic regression analysis showed that the serum levels of anti-smooth muscle antibody on OPU day was the positive predictive factors for live birth following ART cycles in the studied population. Conclusion: No significant effect of COH on the studied autoantibodies by the time of OPU was found but further studies are required to interpret these results. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature
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eprints Iran University of Medical Sciences
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oai:eprints.iums.ac.ir:6392
Last time updated on 10/10/2019
eprints Iran University of Medical Sciences
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:eprints.iums.ac.ir:120
Last time updated on 10/10/2019