Baram, TZ

Brunson, KL

Chen, YC

Colgin, LL

Kramar, E

Lin, B

Lynch, G

English

eScholarship - University of California

UC IrvineUC Irvine Previously Published WorksTitleNeural mechanisms underlying progressive impairment of memory after early life stressPermalinkhttps://escholarship.org/uc/item/39r7v0fwJournalANNALS OF NEUROLOGY, 58ISSN0364-5134AuthorsBrunson, KLKramar, ELin, Bet al.Publication Date2005Copyright InformationThis work is made available under the terms of a Creative Commons Attribution License, availalbe at https://creativecommons.org/licenses/by/4.0/ Peer reviewedeScholarship.org Powered by the California Digital LibraryUniversity of CaliforniaP92. Neural Mechanisms Underlying Progressive Impairment of Memory after Early Life StressKristen L. Brunson, Enikö Kramár, Bin Lin, Yuncai Chen, Laura Lee Colgin, Gary Lynch, and Tallie Z. Baram; Irvine, CAEarly life stress is thought to cause cognitive deficits in adult-hood, but the underlying mechanisms are unknown. Here we provide a neurobiological basis for these disorders in a rat model. Neonatal rats were raised under conditions of chronic emotional stress for a week (postnatal days 2–9) by exposure to fragmented maternal care. As adults, they were tested for two forms of hippocampus-dependent learning and memory. Memory was severely but selectively impaired in middle-aged rats, but these deficits were not evident earlier in adulthood, suggesting that the disturbances were progressive. Upon ex-amining potential underlying deficits in synaptic plasticity, it was found that only the older rats had impaired long-term potentiation in hippocampus. Aberrant mossy fiber sprouting was evident in middle-aged, early life stress rats and may cause a slowly developing cascade that disrupts physiology and plasticity in CA3. In CA1, basic physiology was pre-served, but early life stress eventually led to dendritic atrophy and disturbances in synaptic plasticity. These findings indi-cate that relatively short periods of emotional stress early in life may lead to progressive impairments in memory that emerge only late in adulthood, and may signify accelerated Program and Abstracts, Child Neurology Society S117

Neural mechanisms underlying progressive impairment of memory after early life stress

https://escholarship.org/content/qt39r7v0fw/qt39r7v0fw.pdf

Neural mechanisms underlying progressive impairment of memory after early life stress

Abstract

Similar works

Full text

Available Versions

eScholarship - University of California