Fujiyama, Katsumi

Hoshino, Tazue

Ikeda, Tadasu

Ishimura, Masahiko

Mashiba, Hiroto

Ochi, Hiroshi

Tanaka, Yasushi

Terasawa, Hikari

Tottori University Research Result Repository

BullTMCT 19， 1 -6， 1992 Blood pressure and plasma insulin in acromegaly * Tadasu IKEDA， Hikari TERASA W T:， Masahiko ISHIMURA~ Hiroshi OCHI*， Katsumi FUJIY AMA*， Tazue HOSHINO*， Yasushi T AN AKA* and Hiroto MASHIBT: Tottori University Coflege of Medical Care Technology， and ネTheFirst Department of Internal Medicine， Tottori University School of Medicine， Y onago 683， J apan l It is well known that hypertension may be a common feature of growth hormone ex-cess'之 T0 date， studies of change電inthe level of， and in blood pressure sensitivity to， the hormones such as anti-natriuretic hormone3刈，renln蜘angiotensin2ふ6)，and catecholamines7，8) are frequently contradictory in acromegalics and the mechanism of increased blood pres-sure in the patients remains to be fully elucidated. In recent， hyperinsulinemia (insulin resistant state) is considered to be a pathogenic factor in the hypertension associated with non寸前ulindependent diabetes mellitus and possibly. 'also in essential hypertension9). Hyperinsulinemia is frequently observed in acromegalic patients. These findings prompted us to investigate the correlation between blood pressure and plasma insulin level in acromegalic patients to elucidate the possible role of hyperinsulinemia in an increase of blood pressure. Subject s and methods Nineteen untreated acromegalic patients (nine women and ten men) were recruited from our clinic. All were inp;:ttients and none of them were receiving drug~ affecting in-sulin secretion and blood pressure. The age was 25-69 yr (46.6土 12.8yr， means土 SD).Systolic (first phase) and diastolic (fifth phase) blood pressures were measured to the nearest even digit on the right arm in a supine position following at least a 5-min bed rest with the use of a random-zero sphygmomanometer. Blood pressure was measured at 10:00 am for three days. Each blood pressure was scored by the mean of three measurements. 2 Blood pressure and insulin After an overnight fasting， 75g oral glucose tolerance test was performed. During the test， the subjects were in bed rest， and the blood was drawn from antecubital vein at 0， 30， 60， 120 and 180 min. Blood glucose was measured by glucose oxidase method. Plasma growth hormone (GH) and insulin (lRI) were measured by respective radioimmunoassay using a double antibody method. The sum of plasma GH or IRI at 0， 30， 60， 120 and 180 min was expressed as the .EGH or .EIRI. Transsphenoidal surgical treatment revealed that al patients had had acromegaly due to benign pituitary adenoma. Pearson's coefficient of correlation was applied for statistical analyses. Results According to the W orld Health Organization criteria， three subjects showed normal glucose tolerance， five showed impaired glucose tolerance， and eleven showed diabetic. Basal GH levels were 10-160 ngjml. No significant correlation was observed between mean説oodpressure (MBP， diastolic plus one幽thirdpulse pressure) and basal GH or .EGH. Significant correlation was observed between MBP and IRI level at 120 min (r = 0.57， pく0.02)or .E IRI (r = 0.58， Pく0.02)as shown in Figs. 1 and 2， although no significant correlation was observed between札価Pand basal IRI， body mass index (kgjm2) or blood glucose level. Discussion In acromegaly， no direct relation has been reported between blood pr田sureand plasma growth hormone concentration by Davies et aF) and Snow et allO)， whereas growth hormone level has been reported to be higher in hypertensive acromegalics by McGuffin et al.l) In . the present study， blood pressure revealed not to be correlated with plasma growth ormone level. Therefore， itclearly demonstrated that blood pressure was higher in hyperinsulinemic acromegalics; suggesting that hyperinsulinemia may cause an increase of blood pressure in acromegalics. Insulin is known to increase renal sodium re-absorption， and direct relation-ship has been observed between blood pressure and amount of exchangeable sodium in untreated acromegalics2). Thus insulin-induced sodium retention may contribute to the increase of blood pressure in acromegalic patients. Although Ferrannini et al 12) have reported that plasma. glucose level after oral glucose load， aswell as plasma insulin level， were directly relate4 to hypertension prevalence， inthe present study diabetic acromegalics who had high plasma glucose level were rather hypotensive. Hyperinsulinemia， rather than hyperglycemia， may have an important role in the increase of blood pressure in acromegalics. The diabetic acromegalics may be slightly hypovolemic and consequently their blood pressures would be lower. In the present study the number of subjects examined was very small and the correlation between plasma insulin and blood pressure has not been examined after hypophysectomy. Further studies should be necessary. Ikeda T et al 3 130 . 120 • 掴110卜 • 聞• 企 . 100 0.0 . 出E • 日 . • 聞 . r = 0.57 • 広司•• • 国 80 ~ • 70 ムて。 25 50 75 100 1 R 1 μU/ml Fig. 1 Correlation between mean blood pressure and plasma insulin level .at 120 min MBP : mean blood pressure， IRI : Plasma insulin ・acromegalicswith normal glucose tolerance 企 acromegalicswith impaired glucose tolerance ・diabeticacromegalics Significant correlation was observed between MBP and IRI (r = 0.57， Pく0.02).4 Blood pressure and insulin 130 A 120 • • 1 10ト • • • A A 100 . むの国日 • A • g 棚• r = O. 58 • 件4• • • 出~ • 70 ).-てO 100 200 300 Z 1 R 1 μU/ml Fig. 2 Correlation . between mean blood pressure and sum of plasma insulin level MBP : mean blood pressure， .rIRI: sum of plasma insulin at 0， 30， 60， 120， and 180 min • acromegalics .with normal glucose tolerance . acromegalics with impaired glucose tolerance ・diabeticacromegalics Significant correlation was observed between MBP and .rIRI (r = 0.58， pく0.02).Ikeda T etal 5 Summary Levels of plasma growth hormone (GH) and plasma insulin (IRI) were measured in 19 untreated acromegalic patients (aged 25-69 years) during the 75g oral glucose tolerance test. No significant correlation was observed between mean blood p戸re邸s叩ur陀e(孔MBP，diastolic plus one.φφ.駒剛刷and 180 min) or basal IRI. However， signiflcant correlation was observed between MBP and IRI at 120 min (r= 0.57， pく0.02)or .l'IRI (sum of plasma insulin at 0， 30， 60， 120 and 180 min， r = 0.58， Pく0.02). These results suggest that hyperinsulinemia may be involved in an increase of blood pressure in active acromegalics. References 1. Nabarro JDN， Clin Endocrinol， 26， 48ト512，1987. 2. Davies DL， Beastall GH， Connell JMC， Fraser R， McCruden D， Teasdale GM， J Hypertension， 3 (Supple. 3)， S413-S415， 1985. 3. Jungmann E， Schirmer U， Fassbinder W， A1thoff P岨H，Schwab N， Zeuzem S， Schoffi-ing K， Acta Endocrinol， 117 (Suppl. 287)， 159， 1988. 4. McNight JA， McCance DR， Hadden DR， Kennedy L， Roberts G， Sheridan B， Atkinson AB， J Endocrinol， 117 (Suppl.) ，58， 1988. 5. Ogihara T， Hata T， Maruyama A， Mikami H， Nakamura M， Okada Y， Kumahara Y， J Clin Endocrinol Metab， 48， 159田162，1979. 6. Kar1berg BE， Ottoson AM， Acta Endocrinol， 100‘581・587，1982. 7. Rozenberg 1， Manchon P， Sabatier C， Hazard J， Lhoste F， Acta Endocrinol， 109， 19-24， 1985. 8. VanLoon GR， J Clin Endocrinol Metab， 48， 784-789， 1979. 9. McLellan AR， Connell JMC， Current Opinion in Cardiol， 3， 666-674， 1988. 10. Snow MH， Piercy DA， Robson V， Wilkinson R， Clin Sci， 53， 87-91， 1977. 11. McGuffin WL， Sherman BM， Roth J， Gordon P， Kahn CR， Roberts WC， Frommer PL， Ann Intern Med， 81， 1ト18，1974. 12. Ferrannini E， Haffner SM， Stern MP， Mitchell BD， Natali A， Hazuda HP， Patterson JK， Eur J Clin Invest， 21，280-287， 1991. (Received Septemちer1， 1992) 

Blood pressure and plasma insulin in acromegaly

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Blood pressure and plasma insulin in acromegaly

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