The American Society for Biochemistry and Molecular Biology
Abstract
Background: To improve the effectiveness of chemo- and radiotherapy only in cancer tissue is important for avoiding side effects.
Results: Emi1 depletion enhanced the sensitivity of anticancer reagents and X-ray irradiation in cancer cells.
Conclusion: Emi1 siRNA would be a useful new modality for enhancing the effect of chemo- and radiotherapy in various tumors.
Significance: This work provides new insights regarding synergistic effect of Emi1 knockdown in combination therapies
