Contains fulltext :
                  22475___.PDF (publisher's version ) (Open Access

Avril, M.F.

Bailly, C.

Bastian, B.C.

Hardmeier, T.

Hill, C.M.

Kwee, H.

Potter, C. de

Prade, M.

Renard, N.

Ruiter, D.J.

Spatz, A.

Wechsler, J.

Radboud Repository

Melanoma in childhood: an EORTC-MCG multicenter study on the clinico-pathological aspects

Melanoma in childhood : an EORTC-MCG multicenter study on the clinico-pathological aspects

NARCIS 

SPATZ, A

RUITER, D

HARDMEIER, T

RENARD, N

WECHSLER, J

BAILLY, C

AVRIL, MF

KWEE, H

BASTIAN, BC

HILL, C

DEPOTTER, C

PRADE, M

Ghent University Academic Bibliography

Melanoma in childhood: An EORTC-MCG multicenter study on the clinico-pathological aspects.

Melanoma in children is rare. Nevertheless, it is imperative that clinicians be aware that melanoma does occur in childhood. Yet there is very little information available on the clinicopathologic variations, and the prognostic parameters of melanoma in children. This report presents the results of a multicenter study of 102 lesions originally diagnosed as cutaneous melanoma, conducted among 5 Western European countries and collected during the period 1961-1994. Criteria for inclusion in the study included: (1) diagnosis of cutaneous melanoma; (2) age up to 16 years at diagnosis; and (3) availability of representative microscopic slides. On the basis of the histologic review only, 60 lesions were confirmed as melanoma, and 42 lesions initially diagnosed as melanoma were reclassified as nevi; 31 of the latter contained a predominance of spindle cells. The only significant parameter associated with the development of metastases or fatal outcome was thickness of more than 2.00 mm. The 5-year survival rate observed in this study was 84%. Based an these findings we conclude that considerable over-diagnosis of melanomas in children occurs. In order, therefore, to give consistent epidemiological data on melanomas in children and to improve proper recognition of their diagnostic features, both by clinicians and by pathologists, we propose to set up a central registry of melanomas in children in Europe, under the auspices of the European Organization for Research and Treatment of Cancer.SCOPUS: ar.jFLWINinfo:eu-repo/semantics/publishe

Spatz, Alain

Avril, Marie Françoise

Hill, Catherine

Prade, Michel

Ruiter, Dirk D.J.

Hardmeier, Thomas

Renard, Nathalie

Wechsler, Janine

Bailly, Christiane

Kwee, Herry

Bastian, Boris Christoph

De Potter, Christian

DI-fusion

Melanoma in childhood: An EORTC-MCG multicenter study on the clinico-pathological aspects

Melanoma in childhood : an EORTC-MCG multicenter study on the clinico-pathological aspects

Abstract

Similar works

Full text

Available Versions

Radboud Repository

Radboud Repository

NARCIS

NARCIS

Ghent University Academic Bibliography

DI-fusion