Portable wireless single chip detector for capillary electrophoresis

Abstract

Separation techniques make analysis of complex mixtures easier. Available on the market bench-top size separation/ detection systems are used in common practice of the analyst. Contrary, scientific community provides more and more data each year related to miniaturization and automation of mentioned systems. However, finding a certified, validated and user friendly system on the market can be a challenge. In this work miniature detector, which is operated from the rechargeable Li-ion battery and provides wireless data communication, is presented. Capacitance-to-digital sensor (integrated circuit) was used as whole detector. Carefully routed printed circuit board with stainless steel rods (electrodes) soldered onto it was used as a base for device. The performance of singleended and differential signal acquisition configuration was compared. Designed detector weight was less than 90 grams (microcontroller, battery and data communication module included). The detector was integrated into commercial capillary electrophoresis system and detection characteristics were tested. Calculated limit of quantification for potassium ions is less than 0.4 μM. Other and mentioned issues related to the design of this detector will be presentedBiochemijos katedraVytauto Didžiojo universiteta