CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
Effect of sulfite on red blood cell deformability ex vivo and in normal and sulfite oxidase-deficient rats in vivo
Authors
Aysel. Ağar
O.K. Baskurt
Melek. Bor-Küçükatay
Vural. Küçükatay
Publication date
1 January 2005
Publisher
'Springer Science and Business Media LLC'
Doi
Cite
Abstract
The effect of sulfite, a widely used food additive, on red blood cell deformability ex vivo and in vivo was investigated. Ex vivo experiments were conducted in human blood exposed to sulfite (5, 10 and 20 mM). In vivo experiments were carried out in sulfite oxidase-competent (SOXC) and sulfite oxidase-deficient (SOXD) rats. In the in vivo experiments, sulfite was administered in the form of sodium metabisulfite (Na2S 2O5, 25 mg/kg/day) via drinking water. Vitamin E dissolved in olive oil at a dose of 50 mg/kg was administered by gastric gavages. Red blood cell (RBC) deformability was determined at various fluid shear stresses using an ektacytometer. Ex vivo sulfite exposure to RBC did not affect RBC deformability. In the in vivo experiments, although RBC deformability was not affected by sulfite treatment in SOXD rats, it was found to be significantly increased in SOXC rats. Vitamin E treatment in combination with sulfite caused impairment in RBC deformability in both SOXC and SOXD rats. We suggest that sulfite needs to be oxidized in order to improve RBC deformability. © Springer-Verlag 2005
Similar works
Full text
Available Versions
Pamukkale Üniversitesi Açık Erişim Arşivi
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:acikerisim.pau.edu.tr:1149...
Last time updated on 05/09/2019
Pamukkale Üniversitesi Açık Erişim Arşivi
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:acikerisim.pau.edu.tr:1149...
Last time updated on 05/09/2019
Pamukkale Üniversitesi Açık Erişim Arşivi
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:acikerisim.pau.edu.tr:1149...
Last time updated on 05/09/2019