Many drugs may cause skin reactions, but skin reactions are seen more commonly with psychotropic drugs. Dermatologic adverse effects have increased because use of antidepressant drugs have become more common all over the world. Most of these adverse effects are benign reactions but rarely serious adverse skin reactions might occur due to antidepressant drugs. There were several case reports about dermatologic side effects of antidepressants in the literature. We present two more cases of adverse skin reactions due to antidepressants; a case of erythema multiforme due to bupropion and a case of acute urticaria due to escitalopram
