Objective:There is growing interest in the NIOSH Total Worker Health\uae (TWH) program, specifically in the process of designing and implementing safer, health-promoting work and workplaces. A TWH Research Methodology Workshop was convened to discuss research methods and future needs.Methods:Twenty-six experts in occupational safety and health and related fields reviewed and discussed current methodological and measurement issues and those showing promise.Results:TWH intervention studies face the same challenges as other workplace intervention studies and some unique ones. Examples are provided of different approaches and their applications to TWH intervention studies, and desired developments in the TWH literature.Conclusions:This report discusses and outlines principles important to building the TWH intervention research base. Rigorous, valid methodologic and measurement approaches are needed for TWH intervention as well as for basic/etiologic, translational, and surveillance research.U19 OH011227/OH/NIOSH CDC HHS/United StatesU60OH009762/ACL HHS/United StatesP30 ES005605/ES/NIEHS NIH HHS/United StatesU19 OH008857/OH/NIOSH CDC HHS/United StatesU60 OH009762/OH/NIOSH CDC HHS/United StatesU19 OH008868/OH/NIOSH CDC HHS/United StatesU19OH011232/ACL HHS/United StatesU19 OH008861/OH/NIOSH CDC HHS/United StatesU19 OH010154/OH/NIOSH CDC HHS/United StatesCC999999/Intramural CDC HHS/United StatesU48 DP005008/DP/NCCDPHP CDC HHS/United StatesU19OH008868/ACL HHS/United States2019-11-01T00:00:00Z30407366PMC6221402691