CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
Effects of excess vitamin B6 intake on serum lipid profile and cerebral cortex in rats
Authors
Göksemin. Acar
Aysel. Aǧar
+3 more
Ramazan. Demir
Leyla. Sati
Yasemin Seval. Çelik
Publication date
1 January 2006
Publisher
Abstract
Aim: The present study was undertaken to investigate the effects of dietary excess of vitamin B6 on certain blood parameters [serum total cholesterol, high density lipoprotein (HDL) cholesterol and total lipid] and the cerebral cortex. Materials and Methods: A total of 36 albino rats were included in the study. Saline solution was administered to control groups (CG-10, n = 6 for 10 days; CG-15, n = 6 for 15 days; CG-20, n = 6 for 20 days). The experimental groups (EG-10, n = 6; EG-15, n = 6; EG-20, n = 6) received 5 mg/kg vitamin B6 daily for 10 days, 15 days and 20 days, respectively. Serum total cholesterol, HDL cholesterol and total lipid levels were measured and compared in CGs and EGs. The cerebral cortex tissue samples were examined by electron microscopy. Results: The total serum cholesterol levels were significantly lower (P < 0.05) although serum HDL levels were significantly higher (P < 0.01) in all EGs. Total serum lipid levels were higher in EG-15 and EG-20 groups than in CGs. The structural degenerations in the perikaryon and neuropil were found prominent in EG-15 and EG-20 groups but not in EG-10. Marked damage in the neuronal and neuropilic structure was observed in rats who received long-term high doses of vitamin B6. Based on these results, a relationship between cerebral cortex damage and serum total lipid and HDL levels in the EG-15 and EG-20 groups is suggested. Conclusions: Dietary excess of vitamin B6 intake reduces serum total cholesterol levels, but not serum HDL and total lipid levels, and also causes cerebral cortex damage in long-term treatment. Thus, a careful diet plan and monitoring of vitamin B 6 dose are recommended in patients who are supplemented with this vitamin. © TÜBİTAK
Similar works
Full text
Available Versions
Pamukkale Üniversitesi Açık Erişim Arşivi
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:acikerisim.pau.edu.tr:1149...
Last time updated on 05/09/2019