Background and Design: Antibiotic resistant Propionibacterium acnes is the main etiologic factor for failure of the acne therapy. In this study, the prevalance of antibiotic resistant P.acnes was investigated in our region. Material and Method: One hundred ninty-two acne vulgaris patients admitted to dermatology clinic were included in the study. Demographic and clinical data were recorded. Anaerobic culture was used for the samples collected by detergent scrub technique. Agar dilution technique was chosen for strains' antimicrobial susceptibilities. Results: Propionibacterium acnes was isolated from 117 (60.9%) of 192 acne vulgaris patients. Antibiotic resistance of P.acnes was found in 10 (8.54%) strain. Erythromycin (9 strain), clindamycin (7 strain) and tetracycline (1 strain) resistance was found as 7.7%, 6.0% and 0.9%, respectively. Doxycyline resistance was not found. Conclusion: The prevalance of antibiotic resistant P.acnes is low and therapeutic failure is not expected due to resistant strains. Resistance rates of P.acnes may be detect via community surveillance programmes
