pH-sensitive microcapsules of ketoprofen and mint essence for colon targeting.

Abstract

Microcapsules containing ketoprofen were obtained by a spray drying process starting from a O/A emulsion in presence of different pH-sensitive materials (Eudragit\uae L100, Eudragit\uae S100 and stearic acid) dissolved in the external phase. The influence of formulation factors (oily phase employed for drug solubilisation, type of coating) on the morphology, particle size distribution, drug loading capacity, in-vitro release and ex-vivo permeation characteristics were investigated

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