The loads during daily activities contribute to fixation failure of cemented hip stems. In-vitro preclinical testing so far has consisted of simulating one or two conditions. Only a small percentage of hip implants fail, with a higher failure rate in most active patients. The goal was to define a procedure to assess the long-term effect of the lifestyle of a reasonably active patient on implant micromotions. Thus, a cyclic load of constant amplitude is unsuitable. All activities inducing high loads were included, to replicate the most critical scenario in terms of fatigue. The following motor tasks were simulated: stair climbing and descending, car entry and exit, bathtub entry and exit, and stumbling. An in-vitro simulation running for 15 days was able to replicate the load peaks occurring in 24 years of patient activity. Inducible micromotion and permanent migration were monitored. The load history was successfully applied to two different designs with known clinical performance, yielding significantly different micromotions for the two types. Results from the present load history were compared against a simpler profile including only stair climbing. Results showed that the new load profile is more sensitive to differences and can more easily discriminate between different designs. Part 2 of this work describes a further validation against retrieved implants
