Immunobiological and experimental aspects of malignant astrocytoma: a review.
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Abstract
Immunotherapy may represent an available method in addition to the traditional therapeutic approaches. Starting from 1991, we set up a
cellular model of lymphocytes obtained from peripheral blood
of healthy patients treated with interleukin-2 (IL-2) in order to
study the role of IL-2 in regulating lymphocytes activation. The
lymphocytes responding to IL-2 treatment, named lymphokineactivated killer (LAK) cells, have a killer non MHC restricted
activity, and are able to kill autologous and allogenic glioma
cells