The complex effects of mechanical forces and
growth factors on articular cartilage
development still need to be investigated in
order to identify optimal conditions for
articular cartilage repair. Strictly controlled
in vitro studies under modelled or space
microgravity conditions can improve our
understanding of the fundamental role of
gravity in articular cartilage development.
The main objective of this Topical Team is to
use modelled microgravity as a tool to
elucidate the fundamental science of
cartilage regeneration. Particular attention is,
therefore, given to the effects of physical
forces under altered gravitational conditions,
applied using controlled bioreactor systems,
on cell metabolism, cell differentiation and
tissue development. Specific attention is also
directed toward the potential advantages of
using magnetic resonance methods for the
non-destructive characterisation of scaffolds,
chondrocytes-polymer constructs and tissue
engineered cartilage.
1. Articular Cartilag
