We report on a man with mental retardation and a complex karyotype with cells containing up to three morphologically distinct supernumerary marker chromosomes (SMCs) in most metaphases. Fluorescence in situ hybridization studies using chromosome 15-specific probes characterised the presence of seven SMCs all derived from chromosome 15. The results suggest that the patient originally had a large inv dup(15) containing two copies of the Prader-Willi/Angelman critical region which became mitotically unstable, and by a process of dynamic mosaicism various morphologically distinct SMCs arose. " 2001 Wiley-Liss, Inc.",,,,,,"10.1002/ajmg.1516",,,"http://hdl.handle.net/20.500.12104/41536","http://www.scopus.com/inward/record.url?eid=2-s2.0-0035497749&partnerID=40&md5=2a10699b4d10f0a9728d789611235d67",,,,,,"4",,"American Journal of Medical Genetics",,"28
