Günther, Ulrike

Hanh, Bui Duc

Hartmann, Marcus

Neubert, Reinhard

Wartewig, Siegfried

English

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Drug penetration studied by FTIR methods  Bui Duc Hanh1, Ulrike Günther1, Marcus Hartmann1, Siegfried Wartewig², Reinhard Neubert1,2  Martin-Luther-University Halle-Wittenberg 1Institute of Pharmaceutics and Biopharmaceutics ²Institute of Applied Dermatopharmacy Wolfgang-Langenbeck-Str. 4, D-06120 Halle(Saale)  Non-invasively on-line monitoring of topical drug delivery is an important subject in dermatopharmaceutical research. The FTIR-ATR technique is an accepted and versatile method for studies of drug diffusion through artificial membranes and biological systems. The development of a FTIR-ATR diffusion cell combines the advantages of the Franz diffusion cell with the FTIR-ATR technique. A mathematical model based on well-defined boundary conditions for estimating diffusion coefficients from experimental data was developed.  The accomplishment of a multivariate calibration of the concentration of the model drug urea in the acceptor medium was achievable. In other experiments the lateral diffusion of dithranol in Vaseline formulations into artificial membranes has been investigated by using FTIR mapping and photothermal spectroscopy.    The Open-Access Journal for the Basic Principles of Diffusion Theory, Experiment and Application© 2005, B.D. HanhDiffusion Fundamentals 3 (2005) 31.1 - 31.1 1

Drug penetration studied by FTIR methods

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Drug penetration studied by FTIR methods

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