Granick, Steve

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The Open-Access Journal for the Basic Principles of Diffusion Theory, Experiment and ApplicationSurprises from single-particle imaging of passive and active diffusionSteve GranickUniversity of Illinois, Urbana, Illinois, USAsgranick@illinois.eduThe transport of matter and energy is fundamental in nature and biology. It can occur by passivediffusion and can also be active. Predicated on fluorescence imaging at the single-particle level, thistalk describes quantitative studies of how this can happen, and presents examples of how nontrivialfindings emerge from observing the rare events that underly the overall ensemble-averaged distribu-tion. For example, in living cells, we find that transportation efficiency problems bear a provocativeparallel with polymer chain trajectories with their spatial extent, and with jammed matter in theirtime evolution. A picture emerges in which simple experiments, performed at single-particle andsingle-molecule resolution, can dissect macroscopic phenomena in ways that surprise.References[1] B. Wang, J. Kuo, S.C. Bae, S. Granick: When Brownian diffusion is not Gaussian. Nature Mate-rials 11, 481–485 (2012)[2] K. Chen, B. Wang, J. Guan, S. Granick: Diagnosing heterogeneous dynamics in singlemolecule/particle trajectories. ArXiv:1306.0505 (2013)

Surprises from single-particle imaging of passive and active diffusion

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Surprises from single-particle imaging of passive and active diffusion

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