Antibody-mediated rejection of arterialised venous allografts is inhibited by immunosuppression in rats: Antibody-mediated rejection of arterialised venousallografts is inhibited by immunosuppression in rats

Abstract

We determined in a rat model (1) the presence and dynamics of alloantibodies recognizing MHC complexes on quiescent Brown-Norway (BN) splenic cells in the sera of Lewis (LEW) recipients of Brown-Norway iliolumbar vein grafts under tacrolimus immunosuppression; and (2) the presence of immunoglobulins in the wall of acute rejected vein allografts