C. CAPURSO

CAPURSO A

CELLAMARE S

COLACICCO AM

DEL PARIGI A

MASTROIANNI F

NICOLETTI G

PANZA F

SCALABRINO A.

SOLFRIZZI V

TORRES F

VENEZIANI B

The effect of a spring mineral water from Montecatini (Italy) on bile acid excretion, and lipid and apolipoprotein serum levels was evaluated. The study was conducted in subjects with serum total cholesterol (TC) level &gt;240 mg/dL and LDL cholesterol (LDL-C) &gt;170 mg/dL, over a 9-week period, with 3 weeks of dietary stabilization, 3 weeks of active treatment, and 3 weeks of tap-water treatment as a control period. Serum lipids and apolipoproteins, total and fractionated bile acid excretion, gallbladder motility, and safety parameters were evaluated. Active treatment with mineral water significantly reduced serum TC by 7.5%, LDL-C by 12.5%, TC/HDL-cholesterol ratio by 6.3%, and apolipoprotein B by 6.3%; total fecal bile acid excretion was increased by 98.9%, and gallbladder volume was reduced by 40%. The reduction in serum and LDL-cholesterol levels observed during the active treatment period ran parallel to the increased excretion of bile acids in the stools. We suggest that salt-rich spring water treatment reduces serum and LDL-cholesterol levels in subjects with mild hypercholesterolemia through a mechanism of increased excretion of fecal bile acid sterols

VENDEMIALE, GIANLUIGI

CAPURSO, CRISTIANO

Archivio Istituzionale della Ricerca- Università degli Studi di Foggia

Increased bile acid excretion and reduction of serum cholesterol after crenotherapy with salt-rich mineral water.

Increased bile acid excretion and reduction of serum cholesterol after crenotherapy with salt-rich mineral water.

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Archivio Istituzionale della Ricerca- Università degli Studi di Foggia