Jo, Ae-Jin

Kim, Jung-In

Kim Jung-In

Jo Ae-Jin

University of Szeged

Trends in Natural Product Research – PSE Young Scientists’ Meeting Budapest, June 19th-21st, 2019 89  PO-7 doi: 10.14232/tnpr.2019.po7  Hypolipidemic effect of autumn olive berry in mice fed a high-fat, high-sucrose diet  Jung-In Kim* and Ae-Jin Jo  Department of Smart Foods and Drugs, Inje University, Gimhae, South Korea  *E-mail: fdsnkiji@inje.ac.kr  Autumn olive (Elaeagnus umbellata Thunb.) is a good source of phytochemicals including lycopene [1,2]. It was reported that lycopene exerted antihyperlipidemic effect in atherosclerosis-induced rats [3]. The aim of this study was to investigate the hypolipidemic effect of autumn olive berry (AOB) in mice fed a high-fat, high-sucrose (HFHS) diet. Seven-week-old male C57BL/6J mice were fed a basal diet, a HFHS diet, or the HFHS diet containing 0.4% AOB extract (low AOB, LAOB) or 0.8% AOB extract (high AOB, HAOB) for 12 weeks. After sacrifice, serum triglyceride, cholesterol, LDL-cholesterol, and HDL-cholesterol were measured. Serum triglyceride, cholesterol, and LDL-cholesterol levels of HFHS group were significantly elevated compared with the control group (p<0.05). Consumption of LAOB or HAOB significantly reduced serum triglyceride levels compared with the HFHS group (p<0.05). Serum cholesterol and LDL-cholesterol levels were significantly lower in the HAOB group than in the HFHS group. Serum cholesterol and LDL-cholesterol levels of the LAOB groups were not significantly different from those of the HAOB and HFHS groups. Serum HDL-cholesterol levels of the four groups were not significantly different. These results suggest that AOB could have hypolipidemic effect in mice fed a HFHS diet.  Acknowledgements This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2016R1D1A3B03930584).  References [1] Fordham IM et al. HortScience. 2001; 36:1136-1137. [2] Guo X et al. J Agric Food Chem. 2009; 57:5334–5339. [3] Kumar R et al. Pharmacognosy Res. 2017; 9:161–167.   

Hypolipidemic effect of autumn olive berry in mice fed a high-fat,

high-sucrose diet : [abstract]

http://acta.bibl.u-szeged.hu/62018/1/ysm_2019_089.pdf

Hypolipidemic effect of autumn olive berry in mice fed a high-fat, high-sucrose diet

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