Ferreira, Maria-José U.

Ferreira Maria-José U.

University of Szeged

Trends in Natural Product Research – PSE Young Scientists’ Meeting Budapest, June 19th-21st, 2019 35 PL-11 doi: 10.14232/tnpr.2019.pl11 Exploring plant metabolites to overcome multidrug resistance in cancer chemotherapy   Maria-José U. Ferreira  Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal  E-mail: mjuferreira@ff.ulisboa.pt  Cancer multidrug resistance (MDR) has been considered as one of the major obstacles for a successful chemotherapy. The most significant mechanism is due to the overexpression of transmembrane transporter proteins of the ATP-binding cassette (ABC) superfamily, which act as extrusion pumps for chemotherapeutic agents, decreasing their intracellular concentration. The most important ACB transporters associated with MDR are P-glycoprotein (P-gp), multidrug resistance protein (MRP1) and breast cancer resistance protein (BCRP). Aiming at obtaining plant-derived metabolites with improved MDR-reversing activity, we have evaluated as P-gp modulators a large number of natural compounds and derivatives, with different scaffolds, using both functional and chemosensitivity assays. Several compounds, namely alkaloid derivatives and nitrogen-containing flavonoids were also evaluated, using MRP1 and BCRP-overexpressing cancer cells as models. The anti-MDR potential of compounds was also assessed by evaluating their ability as collateral sensitivity agents, in resistant cancer cells [1-4].  Acknowledgements Fundação para a Ciência e a Tecnologia (FCT), Portugal (projects: PTDC/MED-QUI/30591/2017; SAICTPAC/0019/2015).   References [1] Reis MA et al. J Nat  Prod. 2017; 80:1411-20. [2] Paterna A et al. Eur J Med Chem. 2017; 128:247-57. [3] Paterna A et al. Bioorg Med Chem. 2018; 26:421-34. [4] Ferreira RJ et al. Future Med Chem. 2018; 10:725-41.   

Exploring plant metabolites to overcome multidrug resistance in cancer chemotherapy : [abstract]

http://acta.bibl.u-szeged.hu/61972/1/ysm_2019_035.pdf

Exploring plant metabolites to overcome multidrug resistance in cancer chemotherapy

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