Departemen Obstetri dan Ginekologi FK Unair - RSUD Dr. Soetomo
Abstract
Medical therapy of endometriosis can only be used within a limited time because of arising side effects. One method of medical treatment that was developed for this purpose is using herbal ingredients, the curcumin. The objective of this study was to study the AMH concentration in serum of endometriotic rat model with curcumin supplementation. This experimental study was performed at embryology laboratory Faculty of Veterinary Medicine of Airlangga University, Surabaya, July – October 2011. This was an experimental laboratory tests using 38 female rats (Rattus novergicus) with the inclusion criteria. To make endometriotic rat model, each rat was injected with: both cyclosporin A and ethynil estradiol intramuscularly, human endometrial tissue of benign ovarian tumors intraperitoneally. The endometriotic rat model were randomly divided into two groups. The intervention group was comsuming curcumin 24 mg (240 mg/kg) once daily until fourteen days. The rats were sacrificed and the AMH concentration from serum were measured by ELISA kit assay from Cusabio Biotech, Wuhan, China. There was a significant difference in serum concentration of AMH between curcumin group (44.9 ± 20.1) an placebo group (29.8 ± 11.9) (p < 0.05). In conclusion, the concentration of serum AMH is higher in endometriotic rat models with curcumin supplementation. (MOG 2011:19;96-101
