Sunflower that has Latin name Helianthus annuus L is a family
of Asteraceae. Empirically sunflower leaves have been used as
antimalarial drugs. But until now there is still no scientific evidence about
the effectiveness of sunflower leaf extract as an antimalarial drug. The
objective of this study was to determine the effect of 80% ethanolic
extract of Helianthus annuus L. leaves against mice infected with
Plasmodium berghei. Helianthus annuus L. leaves were macerated using
80% ethanol and tested in vivo using a four-day Peter suppressive test in
mice weighing 20-30 gram. Mice infected with blood donor mice
containing red blood cells infected with Plasmodium berghei with
parasitemia > 20%. The extract would be administered for 4 consecutive
daysorally with dose 0,1; 1; 10; 100 mg / kg body weight if parasite level
in mice reach 1-2%. Blood smear sampling from each rat was performed
to determine the level of parasitemia for five days compared with
untreated subjects, then ED50 was calculated from the analysis of the
inhibition level within five days with probit analysis. The results showed
that ethanol extract of 80% of H. annuus L. leaves the largest dose of 100
mg / kgBW can inhibit 82.05% and have ED50 value of 2.27 mg / kgBW.
Based on the results obtained, further research that can be done is the
antimalarial toxicity test of 80% ethanol extract of Helianthus annuus L
leaves, so it can see the safety of the ethanol extract 80% of leaves
Helianthus annuus L. as antimalarial drugs
