Nutraceuticals represents an intriguing challenge in clinical practice. They are currently used worldwide in all fields of Medicine. The present Supplement reports two Italian surveys concerning a probiotic mixture employed in patients with chronic intestinal disorders and a Medical Device used in patients with upper respiratory diseases. These surveys were conducted on a group of Italian gastroenterologists and on a group of Italian otolaryngologists respectively. Both surveys demonstrated that these compounds may represent a useful therapeutic option in clinical practice