The hypoglycemic potential of crude ethanolic extract of leaves (CEE-Mn) of the Morus nigra
L. (Moraceae) was evaluated in normoglycemic rats. CEE-Mn (200 and 400 mg/kg) and metformin (500
mg/kg) were tested on the glucose tolerance oral test. The acute toxicity of CEE-Mn was performed 2.0
g/kg intraperitoneally and 5.0 g/kg orally in Swiss mice. Blood was removed after seven days for laboratory
analysis of hematological and biochemical parameters. In the glucose tolerance oral test, only metformin
was able to reduce the glucose-induced hyperglycemia. Regarding acute toxicity no mortality and
no toxicity signs were observed, indicating low toxicity of the extract. In the evaluation of hematological
and biochemical parameters no alteration was observed. In conclusion, the CEE-Mn can be considered of
low toxicity but did not produce the expected hypoglycemic effect in the model used.Colegio de Farmacéuticos de la Provincia de Buenos Aire
