The present study involves development and investigation of liposomal system for improving
skin residence of ciclopirox olamine in cutaneous mycosis. Spherical unilamellar liposomes of ciclopirox
olamine were prepared by ethanol injection method. The vesicle size and % entrapment efficiency were in
the range of 196 ± 1.73 to 1040.66 ± 7.02 nm and 34.28 ± 4.4 to 54.89 ± 1.9 respectively. The electrokinetic
potential varied from -52.4 ± 2.0 to -71.7 ± 1.3 mV. A 32 factorial design was utilized to optimize the concentrations
of cholesterol and Phospholipon® 90H. Cholesterol was found to be primarily responsible for
the behaviour of the liposomes as compared to the phospholipid. FTIR study revealed that liposomal encapsulation
preserved the principal characteristic group of ciclopirox olamine required for antifungal action.
In-vitro artificial membrane and ex-vivo excised rat skin studies demonstrated reasonably higher cutaneous
deposition of the drug. Liposomes proved interesting tool for maximizing the drug retention in
skin, an important requisite in treatment of cutaneous fungal infections.Colegio de Farmacéuticos de la Provincia de Buenos Aire
