Manilkara subsericea (Mart.) Dubard (Sapotaceae) is popularly known in Brazil as "guracica". The species from the genus Manilkara have been studied and several substances were found, including triterpenes. In the present study, we describe the anticholinesterasic activity of an extract of M. subsericea containg beta-amyrin acetate (76.3 %) and alpha-amyrin acetate (23.7 %) using a TLC bioassay.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Botas, Gisele da S.

Brito, Monique A. de

Corrêa, Arthur L.

Cruz, Rodrigo A.S.

Fernandes, Caio P.

Rocha, Leandro

Santos, Marcelo G.

Silva Filho, Moacélio V.

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1631ISSN 0326-2383KEY WORDS: Acetylcholinesterase, Jurubatiba, Manilkara subsericea, Sapotaceae, triterpenes.* Author to whom correspondence should be addressed. E-mail: lean@vm.uff.brLatin American Journal of Pharmacy(formerly Acta Farmacéutica Bonaerense)Lat. Am. J. Pharm. 30 (8): 1631-4 (2011)Short communicationReceived: May 31, 2010Revised version: June 13, 2011Accepted: June 16, 2011Anticholinesterasic Activityof Manilkara subsericea (Mart.) Dubard TriterpenesSUMMARY. Manilkara subsericea (Mart.) Dubard (Sapotaceae) is popularly known in Brazil as “guraci-ca”. The species from the genus Manilkara have been studied and several substances were found, includingtriterpenes. In the present study, we describe the anticholinesterasic activity of an extract of M. subsericeacontaing beta-amyrin acetate (76.3 %) and alpha-amyrin acetate (23.7 %) using a TLC bioassay. Caio P. FERNANDES 1, Arthur L. CORRÊA 1, Rodrigo A.S. CRUZ 1, Gisele da S. BOTAS 1,Moacélio V. SILVA-FILHO 2, Marcelo G. SANTOS 3, Monique A. de BRITO & Leandro ROCHA 1* 1 Laboratório de Tecnologia de Produtos Naturais and2 Departamento de Farmácia e Administração Farmacêutica, Faculdade de Farmácia,Universidade Federal Fluminense, Rua Doutor Mário Viana 523, CEP 24241-000, Niterói, RJ, Brazil3 Departamento de Ciências, Faculdade de Formação de Professores,Universidade do Estado  do Rio de Janeiro, Dr. Francisco Portela 1470,CEP 24435-000, São Gonçalo, RJ, Brazil4 Laboratório de Química Medicinal Computacional, Faculdade de Farmácia, Universidade FederalFluminense, Rua Doutor Mário Viana 523, Santa Rosa, CEP 24241-000, Niterói, RJ, Brazil

Anticholinesterasic activity of Manilkara subsericea (Mart.) Dubard triterpenes

El Servicio de Difusión de la Creación Intelectual

1631ISSN 0326-2383
KEY WORDS: Acetylcholinesterase, Jurubatiba, Manilkara subsericea, Sapotaceae, triterpenes.
* Author to whom correspondence should be addressed. E-mail: lean@vm.uff.br
Latin American Journal of Pharmacy
(formerly Acta Farmacéutica Bonaerense)
Lat. Am. J. Pharm. 30 (8): 1631-4 (2011)
Short communication
Received: May 31, 2010
Revised version: June 13, 2011
Accepted: June 16, 2011
Anticholinesterasic Activity
of Manilkara subsericea (Mart.) Dubard Triterpenes
SUMMARY. Manilkara subsericea (Mart.) Dubard (Sapotaceae) is popularly known in Brazil as “guraci-
ca”. The species from the genus Manilkara have been studied and several substances were found, including
triterpenes. In the present study, we describe the anticholinesterasic activity of an extract of M. subsericea
containg beta-amyrin acetate (76.3 %) and alpha-amyrin acetate (23.7 %) using a TLC bioassay. 
Caio P. FERNANDES 1, Arthur L. CORRÊA 1, Rodrigo A.S. CRUZ 1, Gisele da S. BOTAS 1,
Moacélio V. SILVA-FILHO 2, Marcelo G. SANTOS 3, Monique A. de BRITO & Leandro ROCHA 1* 
1 Laboratório de Tecnologia de Produtos Naturais and
2 Departamento de Farmácia e Administração Farmacêutica, Faculdade de Farmácia,
Universidade Federal Fluminense, Rua Doutor Mário Viana 523, CEP 24241-000, Niterói, RJ, Brazil
3 Departamento de Ciências, Faculdade de Formação de Professores,
Universidade do Estado  do Rio de Janeiro, Dr. Francisco Portela 1470,
CEP 24435-000, São Gonçalo, RJ, Brazil
4 Laboratório de Química Medicinal Computacional, Faculdade de Farmácia, Universidade Federal
Fluminense, Rua Doutor Mário Viana 523, Santa Rosa, CEP 24241-000, Niterói, RJ, Brazil


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Anticholinesterasic activity of Manilkara subsericea (Mart.) Dubard triterpenes

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