Cyclotrons in combination with ECR ion sources provide the ability to accelerate "cocktails" of ions. A cocktail is a mixture of ions of near-identical mass-to-charge (m/q) ratio. The different ions cannot be separated by the injector mass-analyzing magnet and are tuned out of the ion source together. The cyclotron then is utilized as a mass analyzer by shifting the accelerating frequency. This concept was developed soon after the first ECR ion source became operational at the 88-Inch Cyclotron and has since become a powerful tool in the field of heavy ion radiation effects testing. Several different "cocktails" at various energies are available at the 88-Inch cyclotron for radiation effect testing, covering a broad range of linear energy transfer and penetration depth. Two standard heavy ion cocktails at 4.5 MeV/nucleon and 10 MeV/nucleon have been developed over the years containing ions from boron to bismuth. Recently, following requests for higher penetration depths, a 15MeV/nucleon heavy ion cocktail has been developed. Up to nine different metal and gaseous ion beams at low to very high charge states are tuned out of the ion source simultaneously and injected together into the cyclotron. It is therefore crucial to balance the ion source very carefully to provide sufficient intensities throughout the cocktail. The paper describes the set-up and tuning of the ion source for the various heavy ion cocktails