In this paper we present measurements of methanesulfonate in the Greenland Ice Sheet Project 2 (GISP2) ice core. Methanesulfonate is an atmospheric oxidation product of dimethylsulfide. The GISP2 methanesulfonate record contains information about the atmospheric loading of biogenic sulfur over the past 110 kyr and its relationship to climate change. The GISP2 data set supports the inferences made from the Renland ice core from Greenland that the glacial atmosphere over Greenland had reduced concentrations of biogenic sulfur compared with the present day [Hansson and Saltzman, 1993]. We conclude that the flux of biogenic sulfur from the North Atlantic Ocean must have been lower during glacial times and speculate that this decrease may have been related to differences in phytoplankton speciation. The data suggest that changes in direct radiative forcing from biogenic sulfur aerosols would act as negative feedback to the glacial/interglacial climate cycles in this region