Coon, H

Dawson, G

Estes, A

Flodman, P

Leong, L

McMahon, WM

Minshew, N

Munson, J

Rodier, PM

Rosenthal, E

Rothstein, J

Schellenberg, GD

Smith, M

Spence, MA

Stodgell, C

Sung, YJ

Wijsman, EM

Yu, CE

Yu, C-E

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UC IrvineUC Irvine Previously Published WorksTitleEvidence for genetic linkage of autism to chromosomes 7 and 4Permalinkhttps://escholarship.org/uc/item/1655k3pdJournalMolecular Psychiatry, 11(11)ISSN1359-4184AuthorsSchellenberg, GDDawson, GSung, YJet al.Publication Date2006-11-01DOI10.1038/sj.mp.4001918Copyright InformationThis work is made available under the terms of a Creative Commons Attribution License, available at https://creativecommons.org/licenses/by/4.0/ Peer reviewedeScholarship.org Powered by the California Digital LibraryUniversity of CaliforniaIMAGEEvidence for genetic linkage of autism to chromosomes7 and 4GD Schellenberg1,2,3, G Dawson4,5, YJ Sung6, A Estes5, J Munson4, E Rosenthal7, J Rothstein7,P Flodman8, M Smith8, H Coon9, L Leong1,2, C-E Yu1,2, C Stodgell10, PM Rodier10, MA Spence8,N Minshew11, WM McMahon9 and EM Wijsman6,71Geriatrics Research Education and Clinical Center, Puget Sound Veterans Affairs Medical Center, Seattle, WA, USA;2Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, WA, USA; 3Departments ofNeurology and Pharmacology, University of Washington, Seattle, WA, USA; 4Department of Psychology and the Center onHuman Development and Disability, University of Washington, Seattle, WA, USA; 5Department of Psychiatry and BehavioralSciences, University of Washington, Seattle, WA, USA; 6Division of Medical Genetics, Department of Medicine, University ofWashington, Seattle, WA, USA; 7Department of Biostatistics, University of Washington, Seattle, WA, USA; 8Department ofPediatrics, University of California, Irvine, CA, USA; 9Division of Child and Adolescent Psychiatry, Department of Psychiatry,University of Utah, Salt Lake City, UT, USA; 10Department of OB/GYN, University of Rochester Medical Center, Rochester, NY,USA and 11Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA-log p4321043210A B  CDEFalocation (cM)-log p0 50 0 50100 150WBS ReelinFOXP2WNT2 EN2bclocation (cM)100 150 200allMOFCreg+reg-phraseworddMolecular Psychiatry (2006) 11, 979. doi:10.1038/sj.mp.4001918The plots are of significance levels for linkage of autism to genetic markers on chromosomes 7 and 4expressed as log 10 of the P-value. The top row (a, c) is for families with a strict diagnosis of autism and thebottom row (b, d) is all families, some with a broader diagnostic classification. The left panes (a, b) are forchromosome 7 and the right panel (b, d) are for chromosome 4. Lines are: all, all families; MO, male-onlyfamilies where all affected subjects are male; FC, female containing families where at least one affectedsubjects is female; regþ , regression positive families; reg-, regression negative families; phrase, age-at-firstphrase as a quantitative trait; word, age-at-first word as a quantitative trait. Locations of chromosome 7 genesare indicated by arrows. WBS, Williams-Beuren syndrome region (85.34–87.4 cM). Bars at the top of (a) arelocations of autism linkage signals from other studies. For more information on this topic, please refer toarticle by Schellenberg et al on pages 1049–1060.Molecular Psychiatry (2006) 11, 979& 2006 Nature Publishing Group All rights reserved 1359-4184/06 $30.00www.nature.com/mp

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Evidence for genetic linkage of autism to chromosomes 7 and 4

Evidence for genetic linkage of autism to chromosomes 7 and 4

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