Cramer, Steven C

Do, An H

King, Christine E

Nenadic, Zoran

Schombs, Andrew

Wang, Po T

eScholarship - University of California

UC IrvineUC Irvine Previously Published WorksTitleBrain-computer Interface Controlled Functional Electrical Stimulation As A Novel Approach To Improving Foot-drop After StrokePermalinkhttps://escholarship.org/uc/item/6wv0d325JournalSTROKE, 44(2)ISSN0039-2499AuthorsDo, An HWang, Po TKing, Christine Eet al.Publication Date2013Copyright InformationThis work is made available under the terms of a Creative Commons Attribution License, availalbe at https://creativecommons.org/licenses/by/4.0/ Peer reviewedeScholarship.org Powered by the California Digital LibraryUniversity of CaliforniaVOLUNTEER WARNING SIGNS DONATE FREE ACCESS | ARTICLEINTERNATIONAL STROKE CONFERENCE POSTER ABSTRACTSBASIC AND TRANSLATIONAL NEUROSCIENCE OF STROKE RECOVERY POSTERS IIAbstract TP94: Brain-computer Interface ControlledFunctional Electrical Stimulation As A Novel Approach ToImproving Foot-drop After StrokeAn H Do, Po T Wang, Christine E King, Andrew Schombs, Zoran Nenadic, and Steven C CramerUniv of California,Irvine, Orange, CAAbstractINTRODUCTION: Foot-drop commonly affects gait after stroke, and current physiotherapy isincompletely effective. Orthoses are often used but benefits disappear on removal. The post-strokebrain has enormous potential to undergo plasticity in support of behavioral recovery. The currentstudy builds on this, using an electroencephalogram (EEG) based brain-computer interface (BCI) tocontrol a functional electrical stimulation (FES) system. Here, motor signals from intact motor cortexare detected then directly applied to the paretic limb to move it, bypassing the stroke. Thisreinforcement of motor cortex activation with supramaximal neuromuscular stimulation may promoteHebbian learning and lead to enduring changes in CNS organization and gait. The current reportdescribes the safety of this system.METHODS: An integrated BCI-FES system for ankle dorsiflexion was developed by the authors.EEG was recorded as subjects alternated between idling and attempted paretic foot dorsiflexion for10 mins. A prediction model was generated from this data and used to classify online EEG intoidling or dorsiflexion states. This model facilitates brain control of the FES device by producingdorsiflexion when a subject’s intent to dorsiflex is detected. Subjects operated the BCI-FES systemby idling or attempting to elicit BCI-FES mediated dorsiflexion in response to alternating 10-seccues. Each run was 200 sec long and was repeated over 1-2 hours, with breaks. Subjectsunderwent 3 weekly sessions.RESULTS: Two patients with stroke (ages 38-60, 22-25 mo post-stroke, NIHSS score 4-9), who hadfoot-drop for which each used a commercial FES system were enrolled and completed the regimen.There were no adverse events and no safety concerns. Both subjects achieved purposeful control ofOriginally published 1 Feb 2013 Stroke. 2013;44:ATP94the BCI-FES system. Active range of motion for dorsiflexion after the BCI-FES regimen increasedfrom 5 to 8° in S1 and from 0 to 3° in S2.CONCLUSIONS: The current study examined a BCI-FES system that aims to promote CNSplasticity based on Hebbian theory. The results provide preliminary evidence that BCI-FES therapyis safe and may lead to neurological improvement. Therapy based on BCI has the potential to help awide range of patients, particularly those with severe impairments.Footnotes  Back to top StrokeAHA JournalsArteriosclerosis, Thrombosis, and Vascular Biology (ATVB)CirculationCirc: Arrhythmia and ElectrophysiologyCirc: Genomic and Precision MedicineCirc: Cardiovascular ImagingCirc: Cardiovascular InterventionsCirc: Cardiovascular Quality & OutcomesCirc: Heart FailureCirculation ResearchHypertensionStrokeJournal of the American Heart Association (JAHA)Journal InformationAbout StrokeEditorial Board

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Brain-computer Interface Controlled Functional Electrical Stimulation As A Novel Approach To Improving Foot-drop After Stroke

https://escholarship.org/content/qt6wv0d325/qt6wv0d325.pdf?t=pri4uw

Brain-computer Interface Controlled Functional Electrical Stimulation As A Novel Approach To Improving Foot-drop After Stroke

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