This article emphasises the importance of natural gestures and describes the framework and the development process of the “Signs Workshop” CD-ROM, which is a multimedia application for the promotion of early
communication skills of children with developmental disabilities. Signs Workshop CD-ROM was created in the scope of Down’s Comm Project, which was financed by the Calouste Gulbenkian Foundation, and is the result of a partnership between UNICA (Communication and Arts Research Unit of the University of Aveiro) and the Portuguese Down Syndrome Association (APPT21/Differences).Calouste Gulbenkian Foundatio