The changes in lymphocyte subpopulations in renal transplant recipients were determined. Prior to immunosuppressive therapy, the subpopulation levels in the recipients were similar to those of healthy adults, but after administration of therapy, the T-cell ratio (%T) decreased, while the IgG-Fc receptor-bearing T-cell ratio (%T.G) increased. However, review of these changes in individual cases showed that among those with the same degree of decrease in %T, the %T.G increased only slightly in some, but markedly in others, thus, indicating that there was not necessarily an inverse correlation between the decrease in %T and increase in %T.G. Further, it is noted that when %T.G was markedly increased, the patient was susceptible to bacterial infection
