Belgrade : Institute of Technical Sciences of SASA
Abstract
Application of synthetic polymer biomaterials is very often used in biomedicine and
dentistry. That’s why the need for creating the new polymer biomaterials is more and more
obvious. Hydroxy-apatite, as a natural constituent of bone, has been already used for many years
in all segments of dentistry. In order to develop better properties, hydroxy-apatite is combined
with polymers. In this research, application of micro and nano composite biomaterials in
reconstruction of osteoporosis damaged alveolar bone of rats is analyzed. Evaluation of
regeneration of restored osteoporosis damaged alveolar bone of rats was done by
histopathological analyses. The optimal results were after 24 weeks after implantation of
calcium-phosphate/poly-D, L-lactide-co-glycolide (CP/DLPLG) composite biomaterials nano
particles in comparison to micro particles. Regeneration and reparation of damaged alveolar
bone with creation of new bone tissue which is very similar to mature bone, are much better on
the place of nano CP/DLPLG implantation. Because of its very good osteoconductive effect,
applied nano CP/DLPLG composite can totally renew lost bone tissue, so it can be the material
of choice for the alveolar bone defect rehabilitation
