Objective: To show the relation between the four parameters associated to bursting discharges
of the thalamic reticular cells (TRNn): the maximum firing frequency (fmax) and the temperature
at which it occurs (Tfmax), the range of temperatures defined as the full width at half maximum
(∆Th
) and the maximum specific low threshold calcium conductance (GT).
Materials and Methods: In order to simulate the TRNn bursting activity, a computational
simulation model was implemented using the NEURON software, which incorporates morphological
and electrophysiological data, and stimuli properties closely related to reality.
Results: It was found that there are nonlinear relations between the parameters. The fmax
frequency follows a quadratic growth with temperature and tends asymptotically towards a
limit value with the maximum calcium conductance. In the same manner, ∆Th increases until
reaching a limit value as function of fmax and GT
. However, the increment per frequency unit is
bigger than the increment per conductance unit.
Conclusions: Four equations were obtained that model the relations between the parameters
associated to bursting discharges of the TRNn in rats and other neurons with similar characteristics
in different animal species
